Flogox is Nutrifarma's natural anti-inflammatory formulated with the active ingredients of ginger, turmeric, bromelain, devil's claw, and vitamin B1.
They they act on inflammation, in all its manifestations: systemic, neuralgia, metabolic of the respiratory, osteo-articular, muscular, digestive, genito-urinary systems, etc…
What is inflammation?
Inflammation is a physiological process aimed at resolving situations that are potentially harmful to the human organism.
The processes that are expressed in the 5 classic signs of inflammation I am:
Rubor – redness from increased blood flow
Pain – pain from bochemical reactions
Heat – increase in temperature
Tumor – swelling due to edema
Functio laesa – inhibition of the functionality of the affected area
The set of these processes is aimed at eliminate the factor that causes inflammation (pathogenic noxa), promoting its elimination in the case of an infectious agent, its expulsion or isolation in the case of a foreign body and triggering the biochemical processes underlying the repair processes and allowing the involved structures to recover their functionality.
This process, when it falls within physiological limits, must not be opposed, as it is the basis of the acute resolution of various morbid conditions. problems arise when The phenomenon tends to become chronic, thus creating a persistent state of inflammation (perhaps even subclinical); or when the inflammatory process, due to particular characteristics of the causative agent, reaches an excessive level, no longer compatible with subsequent repair processes. The inflammatory process itself causes extensive cellular, tissue, and functional damage.
In this case, such processes, can be addressed through the appropriate use of molecules with anti-inflammatory action, including several nutraceutical tools that, through different mechanisms, intervene on the underlying causes of inflammation itself.
5 natural active ingredients of Flogox
GINGER: known in scientific literature as Zingiber officinale, it is a nutraceutical principle with various applicative properties, which can be used for example in both gastroenterology and phlebology.
Making a general evaluation of the properties of ginger it is possible to report ainteresting anti-inflammatory capacity due, according to some authors, mainly to the action of gingerols, phenolic compounds contained in it, one of the most studied of which is [6]-gingerol.
This action occurs both at the level of cyclooxygenases, like nonsteroidal anti-inflammatory drugs, in particular at the level of COX-2, and at the level of lipoxygenases, reducing the synthesis of inflammatory mediators such as prostaglandins and leukotrienes, generating a broad-spectrum anti-inflammatory effect.
Furthermore, some authors report that ginger has anticoagulant-antithrombotic effects due to its potential action on thromboxane A-2, an effect that would potentially make it even more interesting in reducing the edema characteristic of the inflammatory process.
DEVIL'S CLAW: known in scientific literature as harpagophytum procumbens, it has traditionally been a nutraceutical remedy useful in controlling inflammatory conditions, particularly used for joint disorders.
To date, the substances or the substance responsible for its action are not known since the single harpagoside, in which it is generally titrated, has only a reference application for the extraction and standardization process, proving to be individually ineffective as an anti-inflammatory, so it is believed that its efficacy is to be attributed to the phytocomplex (complex of molecules contained in it) or to parts of it.
According to most authors, this action appears to occur at the level of cyclooxygenase-2 (COX-2), with dynamics similar to those of many nonsteroidal anti-inflammatory drugs. Among the most studied applications, those on joints show the greatest potential for action.
VITAMIN B1: also known as thiamine. It plays an important role in the oxidative decarboxylation of pyruvate and α-ketoglutarate in the Krebs cycle (important for the production of metabolic energy) and in the transketolase reaction in the pentose phosphate cycle (important for the production of NADPH and ribose 5-phosphate). Its dietary deficiency leads to metabolic problems, particularly in carbohydrate metabolism, visible within a few days, with an increase in plasma α-ketoacids, and is associated with nervous system disorders, including beriberi and neuropathies of various degrees.
Due to its water-soluble nature, vitamin B1 is not easily stored by the body. Its use may be beneficial in resolving inflammatory conditions affecting components of the nervous system, optimizing its metabolic-energetic dynamics.
TURMERICKnown in scientific literature as curcuma longa, it is a nutraceutical with strong anti-inflammatory properties due primarily to the presence of curcuminoids, particularly curcumin. Curcuminoids exert their effects by regulating numerous molecules underlying the inflammatory process, including cyclooxygenase, lipoxygenase, tumor necrosis factor-α, various interleukins, NF-β, and many others, so much so that some authors have defined it as having a pleiotropic anti-inflammatory effect.
To determine these potentials, its use has been studied in numerous fields: from the purely anti-inflammatory one at the level of various organs and systems to that of prevention or add-on therapy for numerous pathologies where chronic or poorly controlled inflammation constitutes an important pathogenic factor.
A major limitation in the use of turmeric-based extracts is the bioavailability of curcuminoids, a problem that can be solved through various technical-pharmaceutical solutions, including that adopted with liposomal turmeric, which uses a lipid carrier to increase its bioavailability.
BROMELAINBromelain is a plant-derived proteolytic enzyme (from Ananas comosus) that promotes the elimination of protein compounds through lysis. Several studies have demonstrated the potential of bromelain, highlighting its potential for controlling inflammation, including promoting the resolution of edema and its ability to act as an antiplatelet factor. These synergistically contributing effects are particularly beneficial for managing the inflammatory process.
Because of these effects, the use of bromelain has been particularly investigated with interesting results in sports traumatology for tendinitis, fibromyositis, sprains, hematomas, and post-traumatic inflammation.
PIPERINE: it is a molecule extracted from piper nigrum and piper longum widely used as a nutraceutical tool capable of increasing the bioavailability of numerous molecules including curcumin.
Its effect is due to a programmed inhibition of cytochrome P450 3A4, which allows for the delay of the elimination of various molecules, including some used for anti-inflammatory effects, such as curcumin. Possible polytherapy with other drugs metabolized by CYP3A4 can be considered considering the time course of action of piperine, which decreases to less than half at about 180 minutes.
