QUERCETINA “QUERCEFIT”
A widely distributed flavonoid found in nature, made highly bioavailable thanks to Phytosome® delivery technology, it is known for its strong antioxidant and anti-inflammatory properties. Studies have highlighted quercetin's ability to bind to numerous proteases, polymerases, and viral surface proteins, interfering with the mechanisms used by various types of viruses to infect human cells.
Further studies also report potential protective and preventive effects on the frequency of asthma attacks and in controlling the most common signs and symptoms of asthma in milder cases of the disease. While maintaining a very high safety profile, Quercefit® does not alter the antiplatelet activity of the most common antiplatelet agents and does not affect the metabolic control of diabetic patients treated with metformin.
Di Pierro F, Khan A, Bertuccioli A, Maffioli P, Derosa G, Khan S, Khan BA, Nigar R, Ujjan I, Devrajani BR. Quercetin Phytosome® as a potential candidate for managing COVID-19. Minerva Gastroenterol Dietol. 2020 Oct 5. doi: 10.23736/S1121-421X.20.02771-3. Epub ahead of print. PMID: 33016666.
Cesarone MR, Belcaro G, Hu S, Dugall M, Hosoi M, Ledda A, Feragalli B, Maione C, Cotellese R. Supplementary prevention and management of asthma with quercetin phytosome: a pilot registry. Minerva Med. 2019 Dec;110(6):524-529. doi: 10.23736/S0026-4806.19.06319-5. Epub 2019 Sep 27. PMID: 31578841.
Riva A, Corti A, Belcaro G, Cesarone MR, Dugall M, Vinciguerra G, Feragalli B, Zuccarini M, Eggenhoffner R, Giacomelli L. Interaction study between antiplatelet agents, anticoagulants, diabetic therapy and a novel delivery form of quercetin. Minerva Cardioangiol. 2019 Feb;67(1):79-83. doi: 10.23736/S0026-4725.18.04795-3. Epub 2018 Sep 13. PMID: 30226032.
SELENIUM METHIONINE
Selenium, a highly bioavailable amino acid, provides the essential building block for the formation of antioxidant enzymes, which prevent the oxidation of molecules on cell membranes. It contributes to protection from oxidative stress caused by free radicals, which are abundant in the immune response.
ZINC CITRATE
A catalyst for numerous enzymatic reactions, including those involved in the immune response and recovery processes. It promotes the immune response. The citrate form shows good bioavailability and tolerability.
PROTECTED VITAMIN C
A water-soluble vitamin (ascorbic acid) with strong antioxidant activity, it supports immune function. When taken with quercetin, it enhances its stability, and therefore its effectiveness, protecting it from oxidants. It is also involved in collagen biosynthesis and iron absorption. The protected form increases its stability in the stomach, promoting its bioavailability.
Colunga Biancatelli RML, Berrill M, Catravas JD, Marik PE. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Front Immunol. 2020 Jun 19;11:1451. doi: 10.3389/fimmu.2020.01451. PMID: 32636851; PMCID: PMC7318306.
Cerullo G, Negro M, Parimbelli M, Pecoraro M, Perna S, Liguori G, Rondanelli M, Cena H, D’Antona G. The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19. Front Immunol. 2020 Oct 28;11:574029. doi: 10.3389/fimmu.2020.574029. PMID: 33193359; PMCID: PMC7655735.
VITAMINA B2
A water-soluble vitamin essential in the processes underlying energy production, particularly important when the body is exposed to increased demands, such as following a significant immune response.
VITAMIN B6
A water-soluble vitamin involved in energy production, supporting nervous tissue function, and red blood cell production. It also plays an important role in the metabolism of branched-chain amino acids.
FOLIC ACID
A water-soluble vitamin involved in the production of hemoglobin and the metabolism of various amino acids, including methionine (synergistically with betaine), which is essential in detoxification processes. It also plays a central role in the production of energy from carbohydrates, lipids, and amino acids, playing a key role in numerous tissues with high energy demands, such as the nervous system.
BETAINE
It promotes the hepatic utilization of lipids, and demonstrates significant ability to support hydration and cellular nutrient delivery. Its use combats fatigue.
