After age 30, endogenous collagen production begins to physiologically slow down, with a decline that can exceed 40% after age 60. This protein is the backbone of the skin and all connective tissues: it provides structure, strength, and firmness to skin, hair, nails, as well as bones and cartilage.
The results of this process are visible already in the first decades of adulthood: the appearance of wrinkles, skin dehydration, brittle hair, and thin nails. These are not just aesthetic signs, but manifestations of a profound biological decline also linked to oxidative stress, inflammation, and reduced protein synthesis.
Why does skin age? Physiological and environmental causes
Skin ages due to a combination of intrinsic (genetic, hormonal, metabolic) and extrinsic (UV rays, smoking, pollution) factors. This leads to:
– Loss of hydration due to a decrease in hyaluronic acid
– Decrease in dermal density due to degradation of collagen and elastin fibers
– Slowing down of cell regeneration
– Reduction of fibroblast activity
The combined effect is less elastic, thinner, and wrinkle-prone skin, as well as hair and nails that lose vitality and structure.
Key Molecules: How to Nourish Skin, Hair, and Nails from Within
Modern nutraceuticals have identified active compounds that, if taken regularly, can help combat skin aging and improve the quality of connective tissue. These include:
- Iperlage® Collagen: Hydrolyzed marine collagen with a molecular weight between 500–1500 Da, with extremely high bioavailability. It contains glycine, proline, and hydroxyproline, amino acids essential for stimulating fibroblasts and regenerating the extracellular matrix. A systematic study (Miranda et al., 2021) has shown that the use of hydrolyzed collagen improves hydration, elasticity, and reduces wrinkle depth.
- DracoBelle™ Nu: Patented extract from Dracocephalum moldavica. Activates the AMPK and FOXO cellular longevity pathways, stimulates endogenous collagen production, and improves skin parameters. Clinical studies (Wandrey et al., 2021; Mibelle AG) demonstrate a 14.4% increase in hydration, a 6.7% increase in elasticity, and an increase in dermal density after 8 weeks.
- Vitamin C: A cofactor of prolyl hydroxylase, essential for collagen stabilization. A powerful antioxidant that protects against free radical damage and aids in the synthesis of type I collagen.
- Biotin (Vitamin B7): Promotes epidermal regeneration, stimulates hair growth and strengthens nail structure.
- Zinc: An essential mineral for the health of skin, nails, and hair. An enzyme cofactor in protein synthesis and protection from oxidative stress.
The integrative answer: Collagenial Intensive by Nutrifarma
Collagenial Intensive is a comprehensive supplement that meets the needs of mature skin. Formulated with highly bioavailable active ingredients, it combines in a single daily stick:
– Collagen Iperlage® (5 g)
– DracoBelle™ Nu (100 mg)
– Vitamin C (80 mg)
– Biotin (50 µg)
– Zinc (10 mg)
No added sugar, peach flavor, practical and pleasant, it is suitable for cycles of 3 to 6 months.
In synergy with other Nutrifarma products
For a complete anti-aging strategy, Collagenial Intensive can be combined with:
– IALUFLEX: for joint health and tissue elasticity
– COLLAGEN NUTRIPEP: for additional bioavailable peptide protein support
Scientific bibliography
Miranda RB et al. (2021). Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol.
Reilly DM et al. (2024). A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity. Dermatol Res Pract.
Wandrey F et al. (2021). Evaluation of the collagen-boosting effects of a Moldavian dragonhead extract. J Comm Med Public Health Rep.
Mibelle AG Biochemistry. Clinical Benefits of DracoBelle™ Nu. (2023). NCT06059534.
S-1210 – Gene Expression Study on DracoBelle™ Nu in Fibroblasts (2023). Mibelle AG.
